| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in the brain of exposed zebrafish and their unexposed F2 offspring
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| Autores: |
Blanc, Mélanie
Alfonso, Sebastien
Bégout, Marie-laure
Barrachina, Célia
Hyötyläinen, Tuulia
Keiter, Steffen H.
Cousin, Xavier
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| Data: |
2021-02
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| Ano: |
2021
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| Palavras-chave: |
Danio rerio
Persistent-organic pollutant
Neurotoxicity
Brain metabolism
RNA-Seq
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| Resumo: |
Polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are persistent organic pollutants still present in aquatic environments despite their total or partial ban. Previously, we observed that an environmentally realistic mixture of these compounds affects energy balance, growth, and reproduction in exposed zebrafish (F0), and behavior in their unexposed offspring (F1-F4). In the present work, we performed lipidomic and transcriptomic analyses on brains of zebrafish (F0-F2) from exposed and control lineages to identify molecular changes that could explain the observed phenotypes. The use of both technologies highlighted that F0 zebrafish displayed impaired mitochondrial function and lipid metabolism regulation (depletion in triacylglycerols and phospholipids) which can explain disruption of energy homeostasis. A subset of the regulated biological pathways related to energetic metabolism and neurotransmission were inherited in F2. In addition, there were increasing effects on epigenetic pathways from the F0 to the F2 generation. Altogether, we show that the effects of an environmental exposure to PCBs and PBDEs on energetic metabolism as well as neurotransmission extend over 2 generations of zebrafish, possibly due to transgenerational epigenetic inheritance.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00646/75797/76720.pdf
https://archimer.ifremer.fr/doc/00646/75797/76875.docx
https://archimer.ifremer.fr/doc/00646/75797/76876.xlsx
DOI:10.1016/j.scitotenv.2020.142097
https://archimer.ifremer.fr/doc/00646/75797/
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| Editor: |
Elsevier BV
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| Formato: |
application/pdf
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| Fonte: |
Science Of The Total Environment (0048-9697) (Elsevier BV), 2021-02 , Vol. 754 , P. 142097 (9p.)
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| Direitos: |
info:eu-repo/semantics/openAccess
restricted use
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